Pyridine alkaloids with activity in the central nervous system

Simon X Lin; Maurice A Curtis; Jonathan Sperry

doi:10.1016/j.bmc.2020.115820

Pyridine alkaloids with activity in the central nervous system

Bioorg Med Chem. 2020 Dec 15;28(24):115820. doi: 10.1016/j.bmc.2020.115820. Epub 2020 Oct 16.

Authors

Simon X Lin¹, Maurice A Curtis², Jonathan Sperry³

Affiliations

¹ School of Chemical Sciences, University of Auckland, Auckland, New Zealand.
² Centre for Brain Research, University of Auckland, Auckland, New Zealand; Department of Anatomy and Medical Imaging, University of Auckland, Auckland, New Zealand.
³ School of Chemical Sciences, University of Auckland, Auckland, New Zealand. Electronic address: j.sperry@auckland.ac.nz.

Abstract

This review discusses all pyridine alkaloids with CNS activity, their therapeutic potential, and the interesting array of sources whence they originate.

Keywords: Alkaloids; CNS; Natural products; Pyridine.

Publication types

Review

MeSH terms

Alkaloids / chemistry*
Alkaloids / isolation & purification
Alkaloids / metabolism
Alkaloids / therapeutic use
Amphibians / metabolism
Animals
Bacteria / chemistry
Bacteria / metabolism
Central Nervous System Diseases / drug therapy
Central Nervous System Diseases / pathology
Fungi / chemistry
Fungi / metabolism
Nicotine / chemistry
Nicotine / isolation & purification
Nicotine / metabolism
Nicotine / therapeutic use
Plants / chemistry
Plants / metabolism
Pyridines / chemistry*
Receptors, Nicotinic / chemistry
Receptors, Nicotinic / metabolism

Substances

Alkaloids
Pyridines
Receptors, Nicotinic
Nicotine